Lepidium Meyenii Maca Can Increase Sperm Count in Adult Men

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Asian Journal of Andrology
2001 Dec; 3: 301-303

Gustavo F. Gonzales, Amanda Cordova, Carla Gonzales, Arturo Chung, Karla Vega, Arturo Villena
Department of Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura. Universidad Peruana Cayetano Heredia, Lima, Peru



The present study was designed to determine the effect of a 4 month oral treatment with tablets of gelatinized (proprietary extrustion process) Lepidium meyenii Maca on seminal analysis in nine adult normal men aged 24-44 years old.

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Nine men received tablets of maca (1500 or 3000 mg/day) for 4 months.
Seminal analysis was performed according to guidelines of the World Health Organization (WHO).
Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T) and estradiol (E2) were measured before and after treatment.


Treatment with gelatinized maca resulted in increased seminal volume, sperm count per ejaculation, motile sperm count, and sperm motility.

Serum hormone levels were not modified with maca treatment. Increase of sperm count was not related to increased dose of maca.


Maca in gelatinized form improved sperm production and sperm motility by mechanisms not related to LH, FSH, PRL, T and E2.

1 Introduction

Maca is the root of a Peruvian plant Lepidium meyenii Walp.(aka lepidium peruvianum Chacon), growing in the Central Andean Region of Peru between 4000 and 4500 m altitude, mainly in Junin and Cerro de Pasco. This species is described in the catalogue of the flowering plants and gymnosperms of Peru [1] . Maca is traditionally employed, among others, to improve sexuality and fertility.

Oral administration significantly improved the sexual behavior in male rats and mice [2,3]. More recently, it has been demonstrated that maca improves spermatogenesis in male rats [4], however, its effect on sperm production in men had not been assessed prior to this study. The present investigation was designed to study the effect of oral administration of a specially enhanced version of lepidium meyenii known as gelatinized maca on the semen parameters and serum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T) and estradiol (E2) levels in normal male volunteers.

Editor's Note: Gelatinized maca has nothing to do with the capsule type or any actual gelatin content. Gelatinization is an extrusion process developed by Universidad Nacional Agraria La Molina (Lima, Peru) which removes starch content from the crushed root in order to concentrate the active ingredients within. Maca produced by this proprietary extrusion process is marketed in Peru under the brand name MacaSol® and outside of Peru under the brand name MacaSource®

2 Materials and methods

2.1 Maca

Maca (Maca Gelatinizada La Molina) capsules were provided by the University Agraria la Molina. Each capsule contains 500 mg of the root.

2.2 Subjects and treatment

Twelve healthy men, 24-44 years of age, were recruited in the study, but 3 dropped out due to personal reasons during the 4 month treatment period. They had not received any kind of medical treatment for at least 3 months before the study. All the subjects gave written consent to participate in the study after being informed of the purpose, benefit and possible risks of the study.

Among the 9 men with complete data, 6 were married and 3, single. Semen samples were collected by masturbation after a 3 day abstinence and fasting blood samples obtained between 08.00-09.00 h before and at the end of the treatment. Sera were kept frozen until hormone assay. Six subjects received 1500 mg/day, whereas 3, 3000 mg/day of Maca for 4 months.

The study was approved and funded using a grant from the Institutional Review Board of the Scientific Research Office, at the Universidad Peruana Cayetano Heredia.

2.3 Semen analysis

The ejaculate volume, semen consistency, sperm motility, sperm morphology and sperm concentration were assessed according to the WHO manual [5]. Spermatozoa were graded “a” (rapid progressive motility), “b” (slow or sluggish progressive motility), “c” (nonprogressive motility), or “d” (immotility) as recommended by the manual.

2.4 Hormone assay

LH, FSH, and PRL were measured by immunoradiometric assay (IRMA), whereas T and E2 were measured by radioimmunoassay using commercial kits (Diagnostic Product Co, California).

2.5 Statistical analysis

Data were expressed in mean±SEM, if applicable. Statistical analysis was performed by the Student’s t-test.The difference was considered significant when P<0.05.

3 Results

Data on semen analysis are presented in Table 1 (below).

The semen volume, total sperm count, motile sperm count, and sperm motility (Grades a+b) were significantly increased after treatment with Maca (P<0.05). Motility Grade a sperm was also increased, but statistically insignificant. There were no significant differences between the two dosage levels of Maca used.

Maca treatment did not significantly change the levels of the hormones assayed (Table 2).

Table 1.
Semen variables before and 4 months following Maca treatment.

Semen variable Pre-Maca
P value
Volume (mL) 2.23±0.28 2.91±0.28 <0.05
pH 7.47±0.09 7.44±0.07 NS
Sperm count (106/mL) 67.06±18.61 90.33±20.46 NS
Total sperm count(106/mL) 140.95±31.05 259.29±68.17 <0.05
Motile sperm count (106/mL) 87.72±19.87 183.16±47.84 <0.05
Sperm motility grade a (%) 29.00±5.44 33.65±3.05 NS
Sperm motility grade a+b (%) 62.11±3.64 71.02±2.86 <0.05
Normal sperm morphology (%) 75.50±2.02 76.90±1.23 NS

Table 2.
Hormonal levels before and 4 month after Maca treatment.

Hormones Pre-Maca
P value
FSH (mIU/mL) 4.30±1.00 3.51±0.83 NS
LH (mIU/mL) 6.05±0.69 4.76±0.68 NS
PRL (ng/mL) 14.41±2.74 13.00±1.51 NS
T (ng/mL) 6.53±0.81 5.34±0.38 NS
E2 (pg/mL) 32.63±4.46 41.53±6.52 NS

4 Discussion

Semen volume resulted from the contributions of seminal vesicles (60%), prostate (30%) and epididymis (10%) [6]. All these glands are androgen dependent [7]. Sperm motility was also androgen dependent [6]. Maca treatment was able to increase both the semen volume and sperm motility. However, we failed to find any increase in serum testosterone levels during Maca treatment, which may suggest that either bioavailable testosterone or testosterone receptor binding might be augmented.

Another possibility is that Maca may act without the participation of androgen mechanism. This seems to be supported by the fact that the weight of seminal vesicle, a target for androgen action, was not influenced by Maca in adult male rats [4].

In adult male rats, Maca has been shown to be beneficial to spermatogenesis [4]. In the present study, sperm count was increased by Maca without affecting the FSH level. It is possible that Maca may improve the response of Sertoli cells to FSH.

We have demonstrated in women that oral administration of Maca for 2 weeks resulted in an increase in the size of the dominant follicles (unpublished data), which also suggested that Maca may improve the response to FSH. Further studies will be required to clarify this issue. In conclusion, Maca administration in gelatinized form, using minimum dosages of 1500mg per day has been shown to improve sperm production and sperm motility by an average of approximately 200% in normal adult males.


[1] Brako L, Zarucchi JL. Catalogue of the Flowering Plants and Gymnosperms of Peru. St Louis: Missouri Botanical Garden; 1993. p 229.

[2] Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, et al. Effect of lipidic extract from Lepidium meyenii on sexual behavior in mice and rats. Urology 2000; 55: 598-602.

[3] Cicero AF, Bandieri E, Arletti R. Lepidium meyenii Walp improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. Journal of Ethnopharmacology 2001; 75: 225-9.

[4] Gonzales GF, Ruiz A, Gonzales C, Villegas L, Córdova A. Effect of Lepidium meyenii (Maca) rotos, a Peruvian plant on spermatogenesis of male rats. Asian Journal of Andrology 2001; 3:231-3.

[5] World Health Organization. WHO laboratory manual for the examination of human semen and sperm cervical mucus interaction. 4th ed. Cambridge: Cambridge University Press; 1999. p 1-10.

[6] Gonzales GF. Functional structure and ultra structure of seminal vesicles. Arch Androl 1988; 22: 1-13.

[7] Gonzales GF. A test for bioandrogenicity in men attending an infertility service. Arch Androl 1988; 21: 135-42.

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